Version 5.4
Mus musculus Protein: Chst7
Summary
InnateDB Protein IDBP-134330.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chst7
Protein Name carbohydrate (N-acetylglucosamino) sulfotransferase 7
Synonyms 2600013M07Rik; C6ST-2; Gn6st-4; GST5;
Species Mus musculus
Ensembl Protein ENSMUSP00000043222
InnateDB Gene IDBG-134328 (Chst7)
Protein Structure
UniProt Annotation
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N- acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc. {ECO:0000269PubMed:10913333}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Highly expressed in kidney. Expressed at lower level in heart, lung and liver. {ECO:0000269PubMed:10913333}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity
GO:0008146 sulfotransferase activity
GO:0008459 chondroitin 6-sulfotransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006044 N-acetylglucosamine metabolic process
GO:0006790 sulfur compound metabolic process
GO:0030206 chondroitin sulfate biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1891767
InterPro IPR000863 Sulfotransferase domain
IPR016469 Carbohydrate sulfotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00685
PRINTS
PIRSF PIRSF005883
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9EP78
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 60322
UniGene Mm.44827
RefSeq NP_068361
MGI ID
MGI Symbol Chst7
OMIM
CCDS CCDS30040
HPRD
IMGT
EMBL AB040710 AB046929 AF280089 AK011202 BC019204
GenPept AAG48247 AAH19204 BAB13769 BAB27465 BAB40372

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca