InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abcb4

Summary

InnateDB Protein

IDBP-134353.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcb4

Protein Name

ATP-binding cassette, sub-family B (MDR/TAP), member 4

Synonyms

mdr-2; Mdr2; Pgy-2; Pgy2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003717

InnateDB Gene

IDBG-134351 (Abcb4)

Protein Structure

UniProt Annotation

Function

Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00441}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0008559	xenobiotic-transporting ATPase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006855	drug transmembrane transport
GO:0042908	xenobiotic transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0046581	intercellular canaliculus

Protein Structure and Domains

PDB ID

MGI:97569

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR019195 ABC transporter, ATPase, putative
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005
PF09818

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21440