Mus musculus Protein: Hist1h2be
Summary
InnateDB Protein IDBP-134370.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hist1h2be
Protein Name histone cluster 1, H2be
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000089296
InnateDB Gene IDBG-136496 (Hist1h2be)
Protein Structure
UniProt Annotation
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization Nucleus. Chromosome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID MGI:2448380
InterPro IPR000558 Histone H2B
IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00808
PF00125
PRINTS PR00621
PIRSF
SMART SM00427
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZWY9
PhosphoSite PhosphoSite-Q6ZWY9
TrEMBL
UniProt Splice Variant
Entrez Gene 68024
UniGene Mm.486845
RefSeq NP_001277459
MGI ID
MGI Symbol Hist1h2be
OMIM
CCDS CCDS26354
HPRD
IMGT
EMBL AK005407 AK011516 AK030546 AK049948 AL592149 AY158934 AY158936 AY158937 BC019673 BC060304 BC069889
GenPept AAH19673 AAH60304 AAH69889 AAO06244 AAO06246 AAO06247 BAB24007 BAB27670 BAC27014 BAC34000 CAI24894