Version 5.4
Mus musculus Protein: Hivep2
Summary
InnateDB Protein IDBP-134487.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hivep2
Protein Name human immunodeficiency virus type I enhancer binding protein 2
Synonyms MIBP1; Schnurri-2; Shn-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000015645
InnateDB Gene IDBG-134485 (Hivep2)
Protein Structure
UniProt Annotation
Function Specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon- beta genes. It may act in T-cell activation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Expressed in heart, lung, skeletal muscle and liver. In the brain expressed in cerebral cortex, hippocampus, corpora amygdala and cerebellar cortex. {ECO:0000269PubMed:10207097}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID MGI:1338076
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
IPR022755 Zinc finger, double-stranded RNA binding
PFAM PF00096
PF12171
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UHF7
PhosphoSite PhosphoSite-Q3UHF7
TrEMBL
UniProt Splice Variant
Entrez Gene 15273
UniGene Mm.42157
RefSeq NP_034567
MGI ID
MGI Symbol Hivep2
OMIM
CCDS CCDS23704
HPRD
IMGT
EMBL AK137291 AK137384 AK147244 AK147419 Y15907
GenPept BAE23294 BAE23336 BAE27792 BAE27900 CAA75868

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca