Version 5.4
Mus musculus Protein: Twistnb
Summary
InnateDB Protein IDBP-134495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Twistnb
Protein Name TWIST neighbor
Synonyms 2410173G11; 2810024J17Rik; D16Wsu83e;
Species Mus musculus
Ensembl Protein ENSMUSP00000020877
InnateDB Gene IDBG-134493 (Twistnb)
Protein Structure
UniProt Annotation
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:12438708}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001054 RNA polymerase I activity
GO:0003899 DNA-directed RNA polymerase activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005736 DNA-directed RNA polymerase I complex
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID MGI:106292
InterPro IPR005576 RNA polymerase Rpb7, N-terminal
IPR012340 Nucleic acid-binding, OB-fold
PFAM PF03876
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q78WZ7
PhosphoSite PhosphoSite-Q78WZ7
TrEMBL B2RT77
UniProt Splice Variant
Entrez Gene 28071
UniGene Mm.465800
RefSeq NP_758457
MGI ID
MGI Symbol Twistnb
OMIM
CCDS CCDS25877
HPRD
IMGT
EMBL AK010829 AK017016 AK017810 AK153090 BC139162 BC139163 CH466526
GenPept AAI39163 AAI39164 BAB27210 BAB30947 BAC25502 BAE31713 EDL36873

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca