Version 5.4
Mus musculus Protein: Cdca5
Summary
InnateDB Protein IDBP-134506.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdca5
Protein Name cell division cycle associated 5
Synonyms 2610036L13Rik; AL024086; AW536684; C85404;
Species Mus musculus
Ensembl Protein ENSMUSP00000025704
InnateDB Gene IDBG-134504 (Cdca5)
Protein Structure
UniProt Annotation
Function Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269PubMed:21111234}.
Subcellular Localization Nucleus {ECO:0000269PubMed:21111234}. Chromosome {ECO:0000269PubMed:21111234}. Cytoplasm {ECO:0000269PubMed:21111234}. Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006302 double-strand break repair
GO:0007064 mitotic sister chromatid cohesion
GO:0007067 mitotic nuclear division
GO:0007076 mitotic chromosome condensation
GO:0007080 mitotic metaphase plate congression
GO:0051329 interphase of mitotic cell cycle
GO:0071922 regulation of cohesin localization to chromatin
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0008278 cohesin complex
Protein Structure and Domains
PDB ID MGI:1915099
InterPro IPR018605 Sororin protein
PFAM PF09666
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CPY3
PhosphoSite PhosphoSite-Q9CPY3
TrEMBL
UniProt Splice Variant
Entrez Gene 67849
UniGene Mm.23526
RefSeq NP_080686
MGI ID
MGI Symbol Cdca5
OMIM
CCDS CCDS29493
HPRD
IMGT
EMBL AK010540 AK011701 BC029626 BC052904
GenPept AAH29626 AAH52904 BAB27016 BAB27788

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca