InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ferd3l

Summary

InnateDB Protein

IDBP-134512.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ferd3l

Protein Name

Fer3-like (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058994

InnateDB Gene

IDBG-134510 (Ferd3l)

Protein Structure

UniProt Annotation

Function

Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins. {ECO:0000269PubMed:12217327}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected in the developing central nervous system, in particular in embryonic ventral neural tube, brain, and spinal cord. Detected in embryonic intestine. Detected in embryonic and adult thalamus, hypothalamus, midbrain, pons and medulla. {ECO:0000269PubMed:11472856, ECO:0000269PubMed:12217327}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0033504	floor plate development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048468	cell development
GO:0050767	regulation of neurogenesis