InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rgn

Summary

InnateDB Protein

IDBP-134619.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgn

Protein Name

regucalcin

Synonyms

AI265316; GNL; SMP30;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023832

InnateDB Gene

IDBG-134617 (Rgn)

Protein Structure

UniProt Annotation

Function

Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Mainly present in the liver. Weak expression was found in the brain, lung and kidney. {ECO:0000269PubMed:8765750, ECO:0000269PubMed:9278263}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004341	gluconolactonase activity
GO:0005509	calcium ion binding
GO:0008270	zinc ion binding
GO:0030234	enzyme regulator activity

Biological Process

GO:0006874	cellular calcium ion homeostasis
GO:0019853	L-ascorbic acid biosynthetic process
GO:0032781	positive regulation of ATPase activity
GO:0050848	regulation of calcium-mediated signaling