InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rps6ka2

Summary

InnateDB Protein

IDBP-134651.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rps6ka2

Protein Name

ribosomal protein S6 kinase, polypeptide 2

Synonyms

90kDa; D17Wsu134e; p90rsk; pp90rsk; Rps6ka-rs1; Rsk3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024575

InnateDB Gene

IDBG-134649 (Rps6ka2)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004711	ribosomal protein S6 kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0001556	oocyte maturation
GO:0002035	brain renin-angiotensin system
GO:0006468	protein phosphorylation
GO:0007507	heart development
GO:0008285	negative regulation of cell proliferation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0010628	positive regulation of gene expression
GO:0010659	cardiac muscle cell apoptotic process
GO:0018105	peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0045786	negative regulation of cell cycle
GO:0045835	negative regulation of meiosis
GO:0060047	heart contraction
GO:0070613	regulation of protein processing
GO:0071322	cellular response to carbohydrate stimulus

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0016020	membrane
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

MGI:1342290

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR016239 Ribosomal protein S6 kinase II
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06293
PF00433

PRINTS

PR00109

PIRSF

PIRSF000606

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References