InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trpa1

Summary

InnateDB Protein

IDBP-134727.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpa1

Protein Name

transient receptor potential cation channel, subfamily A, member 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043594

InnateDB Gene

IDBG-134725 (Trpa1)

Protein Structure

UniProt Annotation

Function

Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. {ECO:0000269PubMed:12654248, ECO:0000269PubMed:15046718, ECO:0000269PubMed:15483558, ECO:0000269PubMed:15843607}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in inner ear (at protein level). Specifically expressed in a subset of nociceptive neurons. Expressed in the same neurons that TRPV1. In contrast, it is not expressed in neurons expressing TRPM8. Expressed in the superior cervical ganglion. {ECO:0000269PubMed:12654248, ECO:0000269PubMed:15194861, ECO:0000269PubMed:15483558, ECO:0000269PubMed:15843607}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0015267	channel activity

Biological Process

GO:0006816	calcium ion transport
GO:0009409	response to cold
GO:0034220	ion transmembrane transport
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0048265	response to pain
GO:0050955	thermoception
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
GO:0050968	detection of chemical stimulus involved in sensory perception of pain
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport