InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFT88

Summary

InnateDB Protein

IDBP-13474.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFT88

Protein Name

intraflagellar transport 88 homolog (Chlamydomonas)

Synonyms

D13S1056E; DAF19; hTg737; TG737; TTC10;

Species

Homo sapiens

Ensembl Protein

ENSP00000261632

InnateDB Gene

IDBG-13468 (IFT88)

Protein Structure

UniProt Annotation

Function

Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas. {ECO:0000269PubMed:7633404}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0060271	cilium morphogenesis
GO:1902017	regulation of cilium assembly
GO:2000785	regulation of autophagic vacuole assembly

Cellular Component

GO:0005814	centriole
GO:0005929	cilium
GO:0030992	intraciliary transport particle B
GO:0031514	motile cilium
GO:0036064	ciliary basal body

Protein Structure and Domains

PDB ID

InterPro

IPR001440 Tetratricopeptide TPR1
IPR006597 Sel1-like
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019412 Outer membrane protein, IML2, mitochondrial/Tetratricopeptide repeat protein 39
IPR019734 Tetratricopeptide repeat

PFAM