InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Akr1b7

Summary

InnateDB Protein

IDBP-134754.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Akr1b7

Protein Name

aldo-keto reductase family 1, member B7

Synonyms

AR; Avdp; MVDP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000007449

InnateDB Gene

IDBG-134752 (Akr1b7)

Protein Structure

UniProt Annotation

Function

Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. May play a role in the metabolism of xenobiotic aromatic aldehydes (By similarity). The role of MVDP in sperm maturation and storage may be related to its potential capacity to produce fructose, or MVDP may play an osmoregulatory role by producing sorbitol. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004032	alditol:NADP+ 1-oxidoreductase activity

Biological Process

GO:0044255	cellular lipid metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:101918

InterPro

IPR020471 Aldo/keto reductase subgroup
IPR023210 NADP-dependent oxidoreductase domain

PFAM

PF00248

PRINTS

PR00069

PIRSF

PIRSF000097

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21300

PhosphoSite

PhosphoSite-P21300

TrEMBL

Q5M9J9

UniProt Splice Variant

Entrez Gene

11997

UniGene

RefSeq

NP_033861

MGI ID

MGI Symbol

Akr1b7

OMIM

CCDS

CCDS19993

HPRD

IMGT

EMBL

AK002705 BC086929 CH466533 J05663 M81448

GenPept

AAA39773 AAA39774 AAH86929 BAB22299 EDL13689