InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Snx13

Summary

InnateDB Protein

IDBP-134785.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snx13

Protein Name

sorting nexin 13

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038430

InnateDB Gene

IDBG-134783 (Snx13)

Protein Structure

UniProt Annotation

Function

May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis. {ECO:0000250, ECO:0000269PubMed:17077144}.

Subcellular Localization

Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004129	cytochrome-c oxidase activity
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006886	intracellular protein transport
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005743	mitochondrial inner membrane
GO:0005769	early endosome
GO:0031901	early endosome membrane

Protein Structure and Domains

PDB ID

MGI:2661416

InterPro

IPR000342 Regulator of G protein signalling domain
IPR001683 Phox homologous domain
IPR003114 Phox-associated domain
IPR003204 Cytochrome c oxidase, subunit Va/VI
IPR013937 Sorting nexin, C-terminal
IPR013996 PX-associated, sorting nexin 13
IPR016137 Regulator of G protein signalling superfamily

PFAM

PF00615
PF00787
PF02194
PF02284
PF08628

PRINTS

PR01301

PIRSF

SMART

SM00312
SM00313
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt