InnateDB Protein
|
IDBP-134914.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Akirin2
|
Protein Name
|
akirin 2
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000081322
|
InnateDB Gene
|
IDBG-134912 (Akirin2)
|
Protein Structure
|
|
Function |
Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). Required for embryonic development and the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. {ECO:0000250, ECO:0000269PubMed:18066067}.
|
Subcellular Localization |
Nucleus {ECO:0000250UniProtKB:Q53H80}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
7 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0000122
|
negative regulation of transcription from RNA polymerase II promoter
|
GO:0006351
|
transcription, DNA-templated
|
GO:0008284
|
positive regulation of cell proliferation
|
GO:0009790
|
embryo development
|
GO:0010629
|
negative regulation of gene expression
|
GO:0010950
|
positive regulation of endopeptidase activity
|
GO:0032496
|
response to lipopolysaccharide
|
GO:0032755
|
positive regulation of interleukin-6 production
|
GO:0045087
|
innate immune response
|
GO:0045892
|
negative regulation of transcription, DNA-templated
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
|
Cellular Component |
|
PDB ID |
MGI:1889364
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
B1AXD8
|
PhosphoSite |
PhosphoSite-B1AXD8
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
433693
|
UniGene |
Mm.389532
|
RefSeq |
NP_001007590
|
MGI ID |
|
MGI Symbol |
Akirin2
|
OMIM |
|
CCDS |
CCDS18027
|
HPRD |
|
IMGT |
|
EMBL |
AK005836
AL807397
|
GenPept |
BAB24265
CAM16479
|
|
|