InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dcun1d2

Summary

InnateDB Protein

IDBP-134965.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dcun1d2

Protein Name

DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)

Synonyms

AW495713; mFLJ10704;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047208

InnateDB Gene

IDBG-134963 (Dcun1d2)

Protein Structure

UniProt Annotation

Function

Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8- conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:2142792

InterPro

IPR005176 Potentiating neddylation domain
IPR009060 UBA-like

PFAM

PF03556

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BZJ7

PhosphoSite

PhosphoSite-Q8BZJ7

TrEMBL

UniProt Splice Variant

Entrez Gene

102323

UniGene

Mm.415688

RefSeq

NP_001019675

MGI ID

MGI Symbol

Dcun1d2

OMIM

CCDS

CCDS40228

HPRD

IMGT

EMBL

AC130818 AK034394 AK155726 BC052676

GenPept

BAC28695 BAE33403