InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALG1

Summary

InnateDB Protein

IDBP-13505.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALG1

Protein Name

asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000262374

InnateDB Gene

IDBG-13503 (ALG1)

Protein Structure

UniProt Annotation

Function

Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER. {ECO:0000269PubMed:10704531}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Congenital disorder of glycosylation 1K (CDG1K) [MIM:608540]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N- glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO:0000269PubMed:14709599, ECO:0000269PubMed:14973778, ECO:0000269PubMed:14973782}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000030	mannosyltransferase activity
GO:0004578	chitobiosyldiphosphodolichol beta-mannosyltransferase activity
GO:0016757	transferase activity, transferring glycosyl groups

Biological Process

GO:0006486	protein glycosylation
GO:0006488	dolichol-linked oligosaccharide biosynthetic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0009103	lipopolysaccharide biosynthetic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0097502	mannosylation