Version 5.4
Mus musculus Protein: Rnf19a
Summary
InnateDB Protein IDBP-135099.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf19a
Protein Name ring finger protein 19A
Synonyms AA032313; Dorfin; Rnf19; Ubce7ip2; UIP117; XYbp;
Species Mus musculus
Ensembl Protein ENSMUSP00000022890
InnateDB Gene IDBG-135097 (Rnf19a)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:10585566}. Note=Expressed primarily in the XY body of pachytene spermatocytes and in the centrosome of somatic and germ cells in all phases of the cell cycle.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1353623
InterPro IPR001841 Zinc finger, RING-type
IPR002867 Zinc finger, C6HC-type
PFAM PF13639
PF14634
PF01485
PRINTS
PIRSF
SMART SM00184
SM00647
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P50636
PhosphoSite PhosphoSite-P50636
TrEMBL Q3TM18
UniProt Splice Variant
Entrez Gene 30945
UniGene Mm.5181
RefSeq NP_038951
MGI ID
MGI Symbol Rnf19a
OMIM
CCDS CCDS27427
HPRD
IMGT
EMBL AF071560 AF120206 AF120207 AF360999 AK147768 AK166197 BC040769 X71642
GenPept AAF18302 AAF18303 AAG37798 AAH40769 AAK51469 BAE28125 BAE38624 CAA50643

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca