InnateDB Protein
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IDBP-135254.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Brd8
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Protein Name
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bromodomain containing 8
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Synonyms
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2610007E11Rik; 4432404P07Rik; SMAP;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000003876
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InnateDB Gene
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IDBG-135252 (Brd8)
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Protein Structure
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Function |
May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
23 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1925906
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InterPro |
IPR001487
Bromodomain
IPR011650
Peptidase M20, dimerisation domain
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PFAM |
PF00439
PF07687
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PRINTS |
PR00503
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PIRSF |
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SMART |
SM00297
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R3B7
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PhosphoSite |
PhosphoSite-Q8R3B7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
78656
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UniGene |
Mm.45602
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RefSeq |
NP_084423
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MGI ID |
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MGI Symbol |
Brd8
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OMIM |
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CCDS |
CCDS50248
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HPRD |
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IMGT |
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EMBL |
AK032320
AK161689
BC023160
BC025644
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GenPept |
AAH23160
AAH25644
BAC27812
BAE36533
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