Version 5.4
Homo sapiens Protein: IRF2BPL
Summary
InnateDB Protein IDBP-13541.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRF2BPL
Protein Name interferon regulatory factor 2 binding protein-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000238647
InnateDB Gene IDBG-13539 (IRF2BPL)
Protein Structure
UniProt Annotation
Function May contribute to the control of female reproductive function (By similarity). May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in the heart, moderately in skeletal muscle and pancreas, and weakly in brain, kidney, liver, testis, thyroid gland and lymphocytes. {ECO:0000269PubMed:11095982}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046543 development of secondary female sexual characteristics
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR022750 Interferon regulatory factor 2-binding protein 1 & 2, zinc finger
PFAM PF11261
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H1B7
PhosphoSite PhosphoSite-Q9H1B7
TrEMBL
UniProt Splice Variant
Entrez Gene 64207
UniGene Hs.743530
RefSeq NP_078772
HUGO HGNC:14282
OMIM 611720
CCDS CCDS9854
HPRD 10713
IMGT
EMBL AB058768 AC007686 AF063597 AJ277365 AL832320
GenPept AAG43156 BAB47494 CAC10539 CAD38615

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca