InnateDB Protein
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IDBP-135443.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ly96
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Protein Name
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lymphocyte antigen 96
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Synonyms
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ESOP-1; MD-2; MD2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000026881
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InnateDB Gene
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IDBG-135441 (Ly96)
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Protein Structure
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Function |
Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted, extracellular space.
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Disease Associations |
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Tissue Specificity |
Highly expressed in spleen, bone marrow, thymus, liver, kidney, ovary and decidua. Detected at lower levels in testis, small intestine and skin.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1341909
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InterPro |
IPR003172
MD-2-related lipid-recognition domain
IPR014756
Immunoglobulin E-set
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PFAM |
PF02221
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PRINTS |
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PIRSF |
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SMART |
SM00737
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JHF9
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q14AM4
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UniProt Splice Variant |
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Entrez Gene |
17087
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UniGene |
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RefSeq |
NP_058619
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MGI ID |
3VQ2
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MGI Symbol |
Ly96
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OMIM |
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CCDS |
CCDS14832
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HPRD |
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IMGT |
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EMBL |
AB018550
AF168120
AK019283
BC116785
CH466536
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GenPept |
AAF89634
AAI16786
BAA93619
BAB31645
EDL14354
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