InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hebp2

Summary

InnateDB Protein

IDBP-135461.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hebp2

Protein Name

heme binding protein 2

Synonyms

SOUL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020000

InnateDB Gene

IDBG-135459 (Hebp2)

Protein Structure

UniProt Annotation

Function

Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin (By similarity). May have low affinity for heme. {ECO:0000250, ECO:0000269PubMed:15518569}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Mainly localized to the cytoplasm with a much lower abundance in the mitochondrion. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0010917	negative regulation of mitochondrial membrane potential
GO:0010940	positive regulation of necrotic cell death
GO:0035794	positive regulation of mitochondrial membrane permeability