InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ehd1

Summary

InnateDB Protein

IDBP-135504.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ehd1

Protein Name

EH-domain containing 1

Synonyms

AA409636; Past1; RME-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025684

InnateDB Gene

IDBG-135500 (Ehd1)

Protein Structure

UniProt Annotation

Function

Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Plays a role in myoblast fusion. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. {ECO:0000269PubMed:15930129, ECO:0000269PubMed:21177873}.

Subcellular Localization

Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Early endosome membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Preferentially associates with tubular recycling endosomes. Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes.

Disease Associations

Tissue Specificity

Highly expressed in testis. Also expressed in kidney, heart, intestine, and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	15 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0017137	Rab GTPase binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0010886	positive regulation of cholesterol storage
GO:0016197	endosomal transport
GO:0031175	neuron projection development
GO:0032456	endocytic recycling
GO:0034383	low-density lipoprotein particle clearance
GO:0042632	cholesterol homeostasis
GO:0051260	protein homooligomerization
GO:1901741	positive regulation of myoblast fusion
GO:1990090	cellular response to nerve growth factor stimulus
GO:2001137	positive regulation of endocytic recycling

Cellular Component

GO:0005768	endosome
GO:0005769	early endosome
GO:0005811	lipid particle
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030139	endocytic vesicle
GO:0031095	platelet dense tubular network membrane
GO:0031901	early endosome membrane
GO:0048471	perinuclear region of cytoplasm
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome