InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gdap1

Summary

InnateDB Protein

IDBP-135583.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gdap1

Protein Name

ganglioside-induced differentiation-associated-protein 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026879

InnateDB Gene

IDBG-135581 (Gdap1)

Protein Structure

UniProt Annotation

Function

Regulates the mitochondrial network by promoting mitochondrial fission. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16172208}. Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, spinal cord, muscles and intestinal villi. In the central nervous system expressed most prominently in the cortex, cerebellum, thalamus, olfactory bulb, and spinal cord. Expressed also in sciatic nerves and in dorsal root ganglia. {ECO:0000269PubMed:16172208}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0000266	mitochondrial fission
GO:0006626	protein targeting to mitochondrion
GO:0032526	response to retinoic acid

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane
GO:0031307	integral component of mitochondrial outer membrane

Protein Structure and Domains

PDB ID

MGI:1338002

InterPro

IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM