Version 5.4
Mus musculus Protein: Kin
Summary
InnateDB Protein IDBP-135586.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kin
Protein Name antigenic determinant of rec-A protein
Synonyms Kin17;
Species Mus musculus
Ensembl Protein ENSMUSP00000043614
InnateDB Gene IDBG-135584 (Kin)
Protein Structure
UniProt Annotation
Function Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C-terminal domain to RNA in vitro. {ECO:0000250UniProtKB:O60870, ECO:0000269PubMed:15252136, ECO:0000269PubMed:1923796, ECO:0000269PubMed:8670903, ECO:0000269PubMed:8954809}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15252136}. Cytoplasm {ECO:0000269PubMed:15252136}. Note=During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids. {ECO:0000250UniProtKB:O60870, ECO:0000269PubMed:15252136}.
Disease Associations
Tissue Specificity Highly expressed in transformed mouse AtT20 neuroendocrine cells. Expressed at a lower level in testis, kidney, skeletal muscle, liver, lung, spleen, brain and heart and kidney. In testis, expressed at much higher levels in proliferating cells than in differentiating cells. Not detected in embryo. {ECO:0000269PubMed:15252136, ECO:0000269PubMed:1923796, ECO:0000269PubMed:8954809}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006397 mRNA processing
GO:0006974 cellular response to DNA damage stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
Protein Structure and Domains
PDB ID MGI:96676
InterPro IPR019447 DNA/RNA-binding protein Kin17, conserved domain
PFAM PF10357
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K339
PhosphoSite PhosphoSite-Q8K339
TrEMBL
UniProt Splice Variant
Entrez Gene 16588
UniGene
RefSeq NP_079556
MGI ID
MGI Symbol Kin
OMIM
CCDS CCDS15676
HPRD
IMGT
EMBL AK009429 AK167740 AL772367 BC028860 X58472
GenPept AAH28860 BAB26281 BAE39778 CAM13915

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca