InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdc42bpg

Summary

InnateDB Protein

IDBP-135606.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdc42bpg

Protein Name

CDC42 binding protein kinase gamma (DMPK-like)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025681

InnateDB Gene

IDBG-135604 (Cdc42bpg)

Protein Structure

UniProt Annotation

Function

May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250UniProtKB:Q5VT25}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=Concentrates at the leading edge of cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0031532	actin cytoskeleton reorganization
GO:0035556	intracellular signal transduction
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0031252	cell leading edge

Protein Structure and Domains

PDB ID

MGI:2652845

InterPro

IPR000095 CRIB domain
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR014930 Myotonic dystrophy protein kinase, coiled coil
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM