InnateDB Protein
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IDBP-135764.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Perp
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Protein Name
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PERP, TP53 apoptosis effector
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Synonyms
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1110017A08Rik; KCP1; KRTCAP1; PIGPC1; THW;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000019998
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InnateDB Gene
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IDBG-135762 (Perp)
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Protein Structure
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Function |
Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway. {ECO:0000269PubMed:10733530, ECO:0000269PubMed:15797384}.
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Subcellular Localization |
Cell junction, desmosome. Cell membrane; Multi-pass membrane protein. Note=Associated with desmosomes.
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Disease Associations |
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Tissue Specificity |
Expressed in the stratified squamous skin epithelium of the skin and the tongue, but not in simple epithelia (at protein level). Expressed in apoptotic cells. {ECO:0000269PubMed:10733530, ECO:0000269PubMed:15797384}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
0
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1929938
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InterPro |
IPR004031
PMP-22/EMP/MP20/Claudin superfamily
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PFAM |
PF00822
PF13903
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JK95
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PhosphoSite |
PhosphoSite-Q9JK95
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
64058
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UniGene |
Mm.397381
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RefSeq |
NP_071315
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MGI ID |
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MGI Symbol |
Perp
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OMIM |
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CCDS |
CCDS23714
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HPRD |
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IMGT |
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EMBL |
AF249870
AF251009
AK003734
AK009184
AK009190
BC021772
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GenPept |
AAF64306
AAF70261
AAH21772
BAB22968
BAB26126
BAB26130
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