InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Elk1

Summary

InnateDB Protein

IDBP-135805.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elk1

Protein Name

ELK1, member of ETS oncogene family

Synonyms

Elk-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009550

InnateDB Gene

IDBG-135803 (Elk1)

Protein Structure

UniProt Annotation

Function

Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Predominantly expressed in the brain, and to a lesser extent in the heart, liver and muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001047	core promoter binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0009416	response to light stimulus
GO:0030154	cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071394	cellular response to testosterone stimulus
GO:0071396	cellular response to lipid
GO:0071480	cellular response to gamma radiation
GO:1901216	positive regulation of neuron death