InnateDB Protein
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IDBP-135834.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rrm2b
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Protein Name
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ribonucleotide reductase M2 B (TP53 inducible)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000022901
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InnateDB Gene
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IDBG-135832 (Rrm2b)
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Protein Structure
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Function |
Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. {ECO:0000269PubMed:11517226, ECO:0000269PubMed:12858174}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates from cytoplasm to nucleus in response to DNA damage. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
16 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004748
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ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2155865
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InterPro |
IPR000358
Ribonucleotide reductase small subunit
IPR009078
Ferritin-like superfamily
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PFAM |
PF00268
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6PEE3
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PhosphoSite |
PhosphoSite-
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TrEMBL |
D3Z0X2
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UniProt Splice Variant |
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Entrez Gene |
382985
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UniGene |
Mm.473406
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RefSeq |
NP_955770
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MGI ID |
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MGI Symbol |
Rrm2b
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OMIM |
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CCDS |
CCDS27437
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HPRD |
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IMGT |
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EMBL |
AC122291
AK138731
BC058103
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GenPept |
AAH58103
BAE23760
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