InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tfap2d

Summary

InnateDB Protein

IDBP-135932.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tfap2d

Protein Name

transcription factor AP-2, delta

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037699

InnateDB Gene

IDBG-135930 (Tfap2d)

Protein Structure

UniProt Annotation

Function

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. {ECO:0000269PubMed:11522791, ECO:0000305}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in both embryonic and newborn brain. {ECO:0000269PubMed:11522791}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0043524	negative regulation of neuron apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0061379	inferior colliculus development