Version 5.4
| Mus musculus Protein: Hist1h2af | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-136016.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Hist1h2af | ||||||||
| Protein Name | histone cluster 1, H2af | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000072989 | ||||||||
| InnateDB Gene | IDBG-136014 (Hist1h2af) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||||||||
| Subcellular Localization | Nucleus. Chromosome. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2448309 | ||||||||
| InterPro |
IPR002119
Histone H2A IPR003958 Transcription factor CBF/NF-Y/archaeal histone IPR007125 Histone core IPR009072 Histone-fold |
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| PFAM |
PF00808
PF00125 |
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| PRINTS |
PR00620
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| PIRSF | |||||||||
| SMART |
SM00414
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8CGP5 | ||||||||
| PhosphoSite | PhosphoSite-Q8CGP5 | ||||||||
| TrEMBL | Q61668 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 319173 | ||||||||
| UniGene | |||||||||
| RefSeq | NP_783592 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Hist1h2af | ||||||||
| OMIM | |||||||||
| CCDS | CCDS26341 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AY158916 BC125011 X02622 | ||||||||
| GenPept | AAI25012 AAO06226 CAA26476 | ||||||||