InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il22ra2

Summary

InnateDB Protein

IDBP-136031.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il22ra2

Protein Name

interleukin 22 receptor, alpha 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042642

InnateDB Gene

IDBG-136029 (Il22ra2)

Protein Structure

UniProt Annotation

Function

Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. {ECO:0000269PubMed:12700595}.

Subcellular Localization

Secreted {ECO:0000269PubMed:12700595}.

Disease Associations

Tissue Specificity

Highly expressed in lymph nodes and at lower levels in lung, spleen, and thymus. Not expressed in kidney, liver and heart. {ECO:0000269PubMed:15201862}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042017	interleukin-22 binding
GO:0042018	interleukin-22 receptor activity

Biological Process

GO:0019221	cytokine-mediated signaling pathway
GO:0042516	regulation of tyrosine phosphorylation of Stat3 protein
GO:0050728	negative regulation of inflammatory response