Version 5.4
Homo sapiens Protein: CNN2
Summary
InnateDB Protein IDBP-13608.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNN2
Protein Name calponin 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000340129
InnateDB Gene IDBG-13604 (CNN2)
Protein Structure
UniProt Annotation
Function Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Subcellular Localization
Disease Associations
Tissue Specificity Heart and smooth muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0031032 actomyosin structure organization
GO:0032970 regulation of actin filament-based process
GO:0071260 cellular response to mechanical stimulus
Cellular Component
GO:0001725 stress fiber
GO:0005856 cytoskeleton
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000557 Calponin repeat
IPR001715 Calponin homology domain
IPR001997 Calponin
IPR003096 Smooth muscle protein/calponin
PFAM PF00402
PF00307
PRINTS PR00889
PR00888
PIRSF
SMART SM00033
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99439
PhosphoSite PhosphoSite-Q99439
TrEMBL
UniProt Splice Variant
Entrez Gene 1265
UniGene Hs.723390
RefSeq NP_958434
HUGO HGNC:2156
OMIM 602373
CCDS CCDS12054
HPRD 03847
IMGT
EMBL AC004528 AC011558 AK126391 BC141818 BC141833 CH471139 D83735 D86059
GenPept AAI41819 AAI41834 BAA12090 BAA20887 BAG54322 EAW69565 EAW69567 EAW69570

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca