Version 5.4
Homo sapiens Protein: NGB
Summary
InnateDB Protein IDBP-13632.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NGB
Protein Name neuroglobin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000298352
InnateDB Gene IDBG-13630 (NGB)
Protein Structure
UniProt Annotation
Function Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. {ECO:0000269PubMed:11029004, ECO:0000269PubMed:11473128, ECO:0000269PubMed:18416560, ECO:0000269PubMed:21190290, ECO:0000269PubMed:21296891}.
Subcellular Localization Perikaryon {ECO:0000250}. Cytoplasm. Mitochondrion.
Disease Associations
Tissue Specificity Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the subthalamic nucleus and the thalamus. {ECO:0000269PubMed:11029004}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005344 oxygen transporter activity
GO:0005506 iron ion binding
GO:0019825 oxygen binding
GO:0020037 heme binding
Biological Process
GO:0006915 apoptotic process
GO:0015671 oxygen transport
Cellular Component
GO:0005739 mitochondrion
GO:0043204 perikaryon
Protein Structure and Domains
PDB ID
InterPro IPR000971 Globin
IPR009050 Globin-like
PFAM PF00042
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NPG2
PhosphoSite PhosphoSite-
TrEMBL A0M8W9
UniProt Splice Variant
Entrez Gene 58157
UniGene Hs.274363
RefSeq NP_067080
HUGO HGNC:14077
OMIM 605304
CCDS CCDS9856
HPRD 05602
IMGT
EMBL AC007375 AC007954 AF422796 AF422797 AJ245944 AJ245946 AK315395 BC032509 CH471061 DQ008010
GenPept AAF62557 AAF63183 AAH32509 AAL98923 AAL98924 AAY16983 BAG37788 CAC11133 CAC12994 EAW81274

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca