Version 5.4
| Mus musculus Protein: Azin1 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-136413.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Azin1 | ||||||||
| Protein Name | antizyme inhibitor 1 | ||||||||
| Synonyms | 1700085L02Rik; AZI; Oazi; Oazin; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000065544 | ||||||||
| InnateDB Gene | IDBG-136411 (Azin1) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:16916800, PubMed:18062773, PubMed:18508777). Inhibits antizyme-dependent ODC degradation by binding to antizymes (PubMed:18062773). Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. {ECO:0000269PubMed:10698696, ECO:0000269PubMed:16916800, ECO:0000269PubMed:18062773, ECO:0000269PubMed:18369191, ECO:0000269PubMed:18508777}. | ||||||||
| Subcellular Localization | Nucleus {ECO:0000269PubMed:19449338}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed during testis development. {ECO:0000269PubMed:18508777, ECO:0000269PubMed:18973822}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1859169 | ||||||||
| InterPro |
IPR000183
Ornithine/DAP/Arg decarboxylase IPR002433 Ornithine decarboxylase IPR009006 Alanine racemase/group IV decarboxylase, C-terminal IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal IPR029066 PLP-binding barrel |
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| PFAM |
PF00278
PF02784 |
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| PRINTS |
PR01179
PR01182 |
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| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | O35484 | ||||||||
| PhosphoSite | PhosphoSite-O35484 | ||||||||
| TrEMBL | D3Z2P3 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 54375 | ||||||||
| UniGene | Mm.490233 | ||||||||
| RefSeq | NP_061215 | ||||||||
| MGI ID | 3BTN | ||||||||
| MGI Symbol | Azin1 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS37065 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AC167019 AF032128 AK049680 AK088112 AK088671 BC019412 BC043722 | ||||||||
| GenPept | AAB87464 AAH19412 AAH43722 BAC33870 BAC40151 BAC40494 | ||||||||