InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Egr1

Summary

InnateDB Protein

IDBP-136416.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Egr1

Protein Name

early growth response 1

Synonyms

A530045N19Rik; egr; Egr-1; ETR103; Krox-1; Krox-24; Krox24; NGF1-A; NGFI-A; NGFIA; TIS8; Zenk; Zfp-6; Zif268;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069616

InnateDB Gene

IDBG-136414 (Egr1)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 466 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	10 [view]
Protein-DNA	28 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	466 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0035035	histone acetyltransferase binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001975	response to amphetamine
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007611	learning or memory
GO:0007623	circadian rhythm
GO:0009749	response to glucose
GO:0010628	positive regulation of gene expression
GO:0010942	positive regulation of cell death
GO:0030217	T cell differentiation
GO:0030509	BMP signaling pathway
GO:0031667	response to nutrient levels
GO:0032354	response to follicle-stimulating hormone
GO:0032868	response to insulin
GO:0032869	cellular response to insulin stimulus
GO:0033233	regulation of protein sumoylation
GO:0034465	response to carbon monoxide
GO:0034698	response to gonadotropin
GO:0035690	cellular response to drug
GO:0035914	skeletal muscle cell differentiation
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0045471	response to ethanol
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048709	oligodendrocyte differentiation
GO:0051602	response to electrical stimulus
GO:0060291	long-term synaptic potentiation
GO:0070498	interleukin-1-mediated signaling pathway
GO:0071236	cellular response to antibiotic
GO:0071260	cellular response to mechanical stimulus
GO:0071310	cellular response to organic substance
GO:0071317	cellular response to isoquinoline alkaloid
GO:0071320	cellular response to cAMP
GO:0071363	cellular response to growth factor stimulus
GO:0071371	cellular response to gonadotropin stimulus
GO:0071372	cellular response to follicle-stimulating hormone stimulus
GO:0071383	cellular response to steroid hormone stimulus
GO:0071455	cellular response to hyperoxia
GO:0071456	cellular response to hypoxia
GO:0071480	cellular response to gamma radiation
GO:0071504	cellular response to heparin
GO:0071506	cellular response to mycophenolic acid
GO:0071873	response to norepinephrine
GO:0072110	glomerular mesangial cell proliferation
GO:0072303	positive regulation of glomerular metanephric mesangial cell proliferation
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:95295

InterPro

IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
IPR021839 Protein of unknown function DUF3432
IPR021849 Protein of unknown function DUF3446

PFAM

PF00096
PF11914
PF11928

PRINTS

PIRSF

SMART

SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08046