Version 5.4
Mus musculus Protein: Agpat4
Summary
InnateDB Protein IDBP-136433.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Agpat4
Protein Name 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
Synonyms 1500003P24Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000024594
InnateDB Gene IDBG-136431 (Agpat4)
Protein Structure
UniProt Annotation
Function Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO:0000269PubMed:15367102}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed at a high levels in the brain, at intermediate or low levels in skeletal muscles, gut, kidney, spleen and lung. Barely detectable in heart and liver. {ECO:0000269PubMed:15367102}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0008150 biological_process
GO:0008152 metabolic process
GO:0016024 CDP-diacylglycerol biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1915512
InterPro IPR002123 Phospholipid/glycerol acyltransferase
PFAM PF01553
PRINTS
PIRSF
SMART SM00563
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K4X7
PhosphoSite PhosphoSite-Q8K4X7
TrEMBL E9Q6S5
UniProt Splice Variant
Entrez Gene 68262
UniGene
RefSeq NP_080920
MGI ID
MGI Symbol Agpat4
OMIM
CCDS CCDS28389
HPRD
IMGT
EMBL AC136921 AC163746 AF485269 AK005139 AK166917 BC047281
GenPept AAH47281 AAM33375 BAB23837 BAE39115

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca