Version 5.4
Mus musculus Protein: Etf1
Summary
InnateDB Protein IDBP-136445.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Etf1
Protein Name eukaryotic translation termination factor 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000025218
InnateDB Gene IDBG-136443 (Etf1)
Protein Structure
UniProt Annotation
Function Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016149 translation release factor activity, codon specific
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006415 translational termination
GO:0006479 protein methylation
GO:0016032 viral process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2385071
InterPro IPR004403 Peptide chain release factor eRF1/aRF1
IPR005140 eRF1 domain 1/Pelota-like
IPR005141 eRF1 domain 2
IPR005142 eRF1 domain 3
IPR024049 Peptide Chain Release Factor eRF1/aRF1, N-terminal
IPR029064 50S ribosomal protein L30e-like
PFAM PF03463
PF03464
PF03465
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BWY3
PhosphoSite PhosphoSite-Q8BWY3
TrEMBL Q3U6V5
UniProt Splice Variant
Entrez Gene 225363
UniGene Mm.488824
RefSeq NP_659115
MGI ID
MGI Symbol Etf1
OMIM
CCDS CCDS29137
HPRD
IMGT
EMBL AK049607 AK152428 AK152952 AK164020 BC013717
GenPept AAH13717 BAC33839 BAE31210 BAE31619 BAE37589

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca