InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map3k4

Summary

InnateDB Protein

IDBP-136474.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map3k4

Protein Name

mitogen-activated protein kinase kinase kinase 4

Synonyms

D17Rp17; D17Rp17e; MAPKKK4; Mek4b; MEKK 4; Mekk4; mKIAA0213; MTK1; RP17; Rp17a; Tas;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086459

InnateDB Gene

IDBG-136472 (Map3k4)

Protein Structure

UniProt Annotation

Function

Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269PubMed:16157600, ECO:0000269PubMed:9079650}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:16157600}. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles.

Disease Associations

Tissue Specificity

Widely expressed. High expression was found in skeletal muscle, kidney, testis followed by heart brain and lung. Low expression was found in spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0001890	placenta development
GO:0006468	protein phosphorylation
GO:0010225	response to UV-C
GO:0010468	regulation of gene expression
GO:0019100	male germ-line sex determination
GO:0035556	intracellular signal transduction
GO:0043507	positive regulation of JUN kinase activity
GO:0048263	determination of dorsal identity
GO:0060718	chorionic trophoblast cell differentiation
GO:1900745	positive regulation of p38MAPK cascade

Cellular Component

GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1346875

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt