InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp6v1c1

Summary

InnateDB Protein

IDBP-136495.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v1c1

Protein Name

ATPase, H+ transporting, lysosomal V1 subunit C1

Synonyms

1700025B18Rik; U13839;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022904

InnateDB Gene

IDBG-136493 (Atp6v1c1)

Protein Structure

UniProt Annotation

Function

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous. Abundant in brain, liver, kidney and testis. {ECO:0000269PubMed:12527205}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078	hydrogen ion transmembrane transporter activity

Biological Process

GO:0015991

ATP hydrolysis coupled proton transport

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0033180	proton-transporting V-type ATPase, V1 domain
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome