InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UFD1L

Summary

InnateDB Protein

IDBP-1365.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UFD1L

Protein Name

ubiquitin fusion degradation 1 like (yeast)

Synonyms

UFD1;

Species

Homo sapiens

Ensembl Protein

ENSP00000263202

InnateDB Gene

IDBG-1363 (UFD1L)

Protein Structure

UniProt Annotation

Function

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	89 [view]
Protein-Protein	89 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0001501	skeletal system development
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process