InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il17f

Summary

InnateDB Protein

IDBP-136614.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il17f

Protein Name

interleukin 17F

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046960

InnateDB Gene

IDBG-136612 (Il17f)

Protein Structure

UniProt Annotation

Function

Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis. Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation. {ECO:0000269PubMed:15477493}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed by a subset of activated T-cells in the lamina propria. {ECO:0000269PubMed:16990136}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	7 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0019955	cytokine binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006029	proteoglycan metabolic process
GO:0006954	inflammatory response
GO:0016525	negative regulation of angiogenesis
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0042089	cytokine biosynthetic process
GO:0042109	lymphotoxin A biosynthetic process
GO:0045076	regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045408	regulation of interleukin-6 biosynthetic process
GO:0045414	regulation of interleukin-8 biosynthetic process
GO:0045423	regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051216	cartilage development
GO:1900017	positive regulation of cytokine production involved in inflammatory response