InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plg

Summary

InnateDB Protein

IDBP-136617.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plg

Protein Name

plasminogen

Synonyms

AI649309; Pg;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000014578

InnateDB Gene

IDBG-136615 (Plg)

Protein Structure

UniProt Annotation

Function

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity). {ECO:0000250}.Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.

Subcellular Localization

Secreted {ECO:0000250}. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0003824	catalytic activity
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0034185	apolipoprotein binding

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0010812	negative regulation of cell-substrate adhesion
GO:0016525	negative regulation of angiogenesis
GO:0022617	extracellular matrix disassembly
GO:0042246	tissue regeneration
GO:0042730	fibrinolysis
GO:0045087	innate immune response (InnateDB)
GO:0045445	myoblast differentiation
GO:0046716	muscle cell cellular homeostasis
GO:0048771	tissue remodeling
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0051918	negative regulation of fibrinolysis
GO:0051919	positive regulation of fibrinolysis
GO:0060707	trophoblast giant cell differentiation
GO:0060716	labyrinthine layer blood vessel development
GO:0071674	mononuclear cell migration

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0019897	extrinsic component of plasma membrane
GO:0031232	extrinsic component of external side of plasma membrane
GO:0034358	plasma lipoprotein particle
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:97620

InterPro

IPR000001 Kringle
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR003014 PAN-1 domain
IPR003609 Apple-like
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR013806 Kringle-like fold
IPR015420 Peptidase S1A, nudel
IPR023317 Peptidase S1A, plasmin

PFAM

PF00051
PF00089
PF00024
PF09342

PRINTS

PR00722

PIRSF

PIRSF001150

SMART

SM00130
SM00020
SM00473

TIGRFAMs

Post-translational Modifications

Modification

Cross-References