InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fzd6

Summary

InnateDB Protein

IDBP-136653.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fzd6

Protein Name

frizzled homolog 6 (Drosophila)

Synonyms

Fz6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022906

InnateDB Gene

IDBG-136651 (Fzd6)

Protein Structure

UniProt Annotation

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G- protein-dependent mechanism.

Subcellular Localization

Membrane {ECO:0000269PubMed:10097073}; Multi-pass membrane protein {ECO:0000269PubMed:10097073}. Cell membrane {ECO:0000269PubMed:10097073}; Multi-pass membrane protein {ECO:0000269PubMed:10097073}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0031625	ubiquitin protein ligase binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001525	angiogenesis
GO:0001736	establishment of planar polarity
GO:0001843	neural tube closure
GO:0001942	hair follicle development
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007166	cell surface receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007409	axonogenesis
GO:0008406	gonad development
GO:0030168	platelet activation
GO:0030901	midbrain development
GO:0033278	cell proliferation in midbrain
GO:0035567	non-canonical Wnt signaling pathway
GO:0035880	embryonic nail plate morphogenesis
GO:0042472	inner ear morphogenesis
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016327	apicolateral plasma membrane
GO:0032589	neuron projection membrane
GO:0045177	apical part of cell