InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde7b

Summary

InnateDB Protein

IDBP-136721.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde7b

Protein Name

phosphodiesterase 7B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020165

InnateDB Gene

IDBG-136719 (Pde7b)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0046872	metal ion binding

Biological Process

GO:0006198	cAMP catabolic process
GO:0007165	signal transduction

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1352752

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt