Version 5.4
| Mus musculus Protein: Lrrtm2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-136750.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Lrrtm2 | ||||||||
| Protein Name | leucine rich repeat transmembrane neuronal 2 | ||||||||
| Synonyms | AI851755; BB129880; C630011A14Rik; mKIAA0416; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000089225 | ||||||||
| InnateDB Gene | IDBG-136748 (Lrrtm2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized to excitatory synapses. {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed in neuronal tissues. {ECO:0000269PubMed:12676565}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2389174 | ||||||||
| InterPro |
IPR001611
Leucine-rich repeat IPR003591 Leucine-rich repeat, typical subtype |
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| PFAM |
PF00560
PF13504 PF13855 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00369
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8BGA3 | ||||||||
| PhosphoSite | PhosphoSite-Q8BGA3 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 107065 | ||||||||
| UniGene | Mm.474882 | ||||||||
| RefSeq | NP_821072 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Lrrtm2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS50251 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK043173 AK043784 AK044705 AK046818 AK049920 AK122278 AY182027 | ||||||||
| GenPept | AAO67548 BAC31484 BAC31653 BAC32042 BAC32883 BAC33985 BAC65560 | ||||||||