Version 5.4
| Mus musculus Protein: Tram2 | |||||
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| Summary | |||||
| InnateDB Protein | IDBP-136849.6 | ||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
| Gene Symbol | Tram2 | ||||
| Protein Name | translocating chain-associating membrane protein 2 | ||||
| Synonyms | |||||
| Species | Mus musculus | ||||
| Ensembl Protein | ENSMUSP00000047992 | ||||
| InnateDB Gene | IDBG-136847 (Tram2) | ||||
| Protein Structure |
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| UniProt Annotation | |||||
| Function | Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding (By similarity). {ECO:0000250}. | ||||
| Subcellular Localization | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. | ||||
| Disease Associations | |||||
| Tissue Specificity | |||||
| Comments | |||||
| Interactions | |||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||
| PDB ID | MGI:1924817 | ||||
| InterPro |
IPR006634
TRAM/LAG1/CLN8 homology domain IPR013599 TRAM1-like protein IPR016447 Translocation associated membrane protein |
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| PFAM |
PF03798
PF08390 |
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| PRINTS | |||||
| PIRSF |
PIRSF005449
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| SMART |
SM00724
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| TIGRFAMs | |||||
| Post-translational Modifications | |||||
| Modification | |||||
| Cross-References | |||||
| SwissProt | Q924Z5 | ||||
| PhosphoSite | PhosphoSite-Q924Z5 | ||||
| TrEMBL | |||||
| UniProt Splice Variant | |||||
| Entrez Gene | 170829 | ||||
| UniGene | Mm.273241 | ||||
| RefSeq | NP_803128 | ||||
| MGI ID | |||||
| MGI Symbol | Tram2 | ||||
| OMIM | |||||
| CCDS | CCDS14846 | ||||
| HPRD | |||||
| IMGT | |||||
| EMBL | AK082751 AY029530 BC018212 | ||||
| GenPept | AAH18212 AAK40298 BAC38601 | ||||