InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gnai1

Summary

InnateDB Protein

IDBP-136918.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnai1

Protein Name

guanine nucleotide binding protein (G protein), alpha inhibiting 1

Synonyms

AU046200; Gialpha1; Gnai-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074259

InnateDB Gene

IDBG-136916 (Gnai1)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody. Localized at the plasma membrane during each stage of mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0031821	G-protein coupled serotonin receptor binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0051301	cell division

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005813	centrosome
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0030496	midbody
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95771

InterPro

IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001408 G-protein alpha subunit, group I
IPR002975 Fungal G-protein, alpha subunit
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011025 G protein alpha subunit, helical insertion
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503
PF00025

PRINTS

PR00318
PR00441
PR01241
PR00328

PIRSF

SMART

SM00275

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt