InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSTZ1

Summary

InnateDB Protein

IDBP-13693.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTZ1

Protein Name

glutathione transferase zeta 1

Synonyms

GSTZ1-1; MAAI; MAI;

Species

Homo sapiens

Ensembl Protein

ENSP00000354959

InnateDB Gene

IDBG-13687 (GSTZ1)

Protein Structure

UniProt Annotation

Function

Bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T- butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. {ECO:0000269PubMed:10739172}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Mostly expressed in liver followed by kidney, skeletal muscle and brain. Also expressed in melanocytes, synovium, placenta, breast and fetal liver and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004364	glutathione transferase activity
GO:0004602	glutathione peroxidase activity
GO:0005515	protein binding
GO:0016034	maleylacetoacetate isomerase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006559	L-phenylalanine catabolic process
GO:0006572	tyrosine catabolic process
GO:0006749	glutathione metabolic process
GO:0006805	xenobiotic metabolic process
GO:0009072	aromatic amino acid family metabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR005955 Maleylacetoacetate isomerase
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM