Mus musculus Protein: Hist1h2bb
Summary
InnateDB Protein IDBP-136969.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hist1h2bb
Protein Name histone cluster 1, H2bb
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000097294
InnateDB Gene IDBG-136967 (Hist1h2bb)
Protein Structure
UniProt Annotation
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization Nucleus. Chromosome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID MGI:2448377
InterPro IPR000558 Histone H2B
IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00808
PF00125
PRINTS PR00621
PIRSF
SMART SM00427
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q64475
PhosphoSite PhosphoSite-Q64475
TrEMBL
UniProt Splice Variant
Entrez Gene 319178
UniGene
RefSeq NP_783595
MGI ID
MGI Symbol Hist1h2bb
OMIM
CCDS CCDS26363
HPRD
IMGT
EMBL AL590388 AY158938 BC116853 BC116857 X80328
GenPept AAI16854 AAI16858 AAO06248 CAA56576 CAI25842