InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc23a1

Summary

InnateDB Protein

IDBP-136972.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc23a1

Protein Name

solute carrier family 23 (nucleobase transporters), member 1

Synonyms

D18Ucla2; Slc23a2; SVCT1; YSPL3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025212

InnateDB Gene

IDBG-136970 (Slc23a1)

Protein Structure

UniProt Annotation

Function

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0008520	L-ascorbate:sodium symporter activity
GO:0015081	sodium ion transmembrane transporter activity
GO:0015229	L-ascorbic acid transporter activity
GO:0033300	dehydroascorbic acid transporter activity
GO:0070890	sodium-dependent L-ascorbate transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006814	sodium ion transport
GO:0007420	brain development
GO:0009636	response to toxic substance
GO:0015882	L-ascorbic acid transport
GO:0030324	lung development
GO:0035461	vitamin transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:0070837	dehydroascorbic acid transport
GO:0070904	transepithelial L-ascorbic acid transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005903	brush border
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0043229	intracellular organelle
GO:0070062	extracellular vesicular exosome